For me, the creepiest is the disappearance of a Canadian boy named Michael Dunahee, then aged 4. He vanished from a school playground with his parents close by and there no witnesses.
There's a famous Japanese case where a mother said she's going to meet an old classmate, left the house leaving an 18 month old baby behind and never came back.
What was really creepy about it was when the husband was being interviewed on TV, there was a memo on the wall that said "Don't believe in anything Yoko says." Yoko was the name of the missing lady's sister.
A girl in my grade (when I was in grade 6) was reportedly missing after having an argument with her mom in the parking lot of a grocery store. Security cameras were checked and they found out the mother had lied about that. After several days we found out that the mom had strangled her with twine, pulled her pants off to make her look like she was raped, and threw her by a lake. Disturbing stuff. There were only about 30 people in my grade so it was a close knit community
Edit: it turns out it was because the mom's boyfriend at the time gave her an ultimatum. Great guy
Edit 2: actually he may not have given the ultimatum, and to my understanding wasn't charged. Mom's evil though and in prison for life
Edit 3: also apparently the last words: "mommy don't" will forever resonate in the mother's head while she's in jail for the rest of her life. This is such a twisted story, ugh.
My would-be aunt was abducted and presumably murdered when she was a young girl, 7yo iirc. The primary suspect was Ted Bundy, who lived down the street and was 14 at the time. My grandmother wrote to him while he was on death row and he wrote back denying responsibility. My mom and the deceased shared a bedroom and were very close in age. There's a book about it. Very creepy in general but especially to me considering it could have easily been my mom and I never would have existed.
The woman in the article below is my deceased grandmother.
Ohhhhh this girl who was working alone got dragged out of gas station (all seen on camera). The footage was so bad they couldnt figure out who it was so they put out a message in the paper with his coat description. Someone eventually says their janitor always wears that coat. They go to the guys house and search non stop over and over again. They find a single burned tooth in the backyard. It would have been inconclusive but the girl had gone to a dentist conference and got a just on the market filling that only like 2 people in the world had.... soo they caught him ....
The Brandon Lawson case
Around 2am he was in a field in Texas and called 911. In the call its hard to hear what he says but he sounds distressed and panicked. He cuts off and that was the last he was heard of. His brother said he called him after but he has yet to be found
It sounds like said he ran into something and mentions he was chased in the woods. Somewhere else someone edited the audio and it sounds like gunshots in the background of the call
Allegedly at 1:03 you can barely hear a faint "help me"
The 911 Call
I was informed by some Redditors that he had a felony warrant out for his arrest so he was more scared of whatever he encountered than he was of going to jail because he specifically requested the cops regardless
It's solved now but the Colleen Stan case always sticks with me. She accepted a ride from a couple with a young baby thinking they looked safe and they were anything but. They held her captive as a sex slave for 7 years, many days she spent 22-23 hours in a box under their bed. The wife even gave birth on the bed above her. She was allowed to go home once and visit her family, she was so brainwashed she didn't tell them what was happening and went back to the box afterwards. The wife finally helped her escape when the husband started building a dungeon for more slaves. It really other me.
Two of them:
Brandon Swanson. On the phone with his dad when he exclaims "oh shit!" and is never heard from or seen again. https://m.youtube.com/watch?v=N0aGru0A4dg
Sarah and Jacob Hoggle. Their mother took them "somewhere safe" and has never told anyone where that was or what happened. She also apparently has paranoid schizophrenia and is not competent to stand trial.http://www.nbcwashington.com/news/local/Mom-of-Missing-Children-Appears-in-Court-Monday-369659471.html
The Schulze Family from Drage in Lower Saxony. Husband Marco (41 at the time), his wife Sylvia (43 at the time), and their daughter Miriam (12 at the time), went missing from their home in Drage on the 22nd july 2015, nowhere to be found. Marcos body was found a week later in the Elbe (a river), he had a concrete block attached to his legs with a rope. Sylvia and Miriam though remain unfound to this day. Their house was just emptied of all their personal belongings and everything, it will be sold, the money will be put in a secure bank account until they find out who will inherit it. Sylvia can't be pronounced dead yet, earliest in 8 years from now on, 10 years after her disappearance. Miriam on the other hand can't be pronounced dead until she is 25, that is the law here in Germany. Many people believe that either the dad killed his wife, daughter, then himself. Others believe mother and daughter are alive. Who knows though, we will may never know.
In India we use gas cylinder for the stoves to cook stuff. And they need to be refilled every 3 week or so. The refill company sends cylinder trucks to remote areas. This time my aunt missed the truck and she send my cousin to near town (~10km) to refill it. My cousin (17 M) at that time left on his bike and never came back. No evidence of him, nothing at all. Police dropped the search after an year and family stopped after like 5 years. He just vanished that day. Almost 20 years now and my aunt is still waiting for his return.
While many people live their lives in search of closure, at times they do need to be in seclusion. But seclusion also has a negative tone to it, just like these creepy things that happened to people when they spent too much time by themselves.